Host-directed therapies for infectious diseases: current status, recent progress, and future prospects.
Identifieur interne : 000187 ( Main/Exploration ); précédent : 000186; suivant : 000188Host-directed therapies for infectious diseases: current status, recent progress, and future prospects.
Auteurs : Alimuddin Zumla [Royaume-Uni] ; Martin Rao [Suède] ; Robert S. Wallis [Afrique du Sud] ; Stefan H E. Kaufmann [Allemagne] ; Roxana Rustomjee [Afrique du Sud] ; Peter Mwaba [Zambie] ; Cris Vilaplana [Espagne] ; Dorothy Yeboah-Manu [Ghana] ; Jeremiah Chakaya [Kenya] ; Giuseppe Ippolito [Italie] ; Esam Azhar [Arabie saoudite] ; Michael Hoelscher [Allemagne] ; Markus Maeurer [Suède]Source :
- The Lancet. Infectious diseases [ 1474-4457 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Interactions hôte-pathogène, Maladies transmissibles.
- usage thérapeutique : Anticorps monoclonaux, Cytokines, Vitamines.
- Humains, Maladies transmissibles, Résistance aux substances, Thérapie cellulaire et tissulaire.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antibodies, Monoclonal, Cytokines, Vitamins.
- immunology : Communicable Diseases, Host-Pathogen Interactions.
- methods : Cell- and Tissue-Based Therapy.
- therapy : Communicable Diseases.
- Drug Resistance, Humans.
Abstract
Despite extensive global efforts in the fight against killer infectious diseases, they still cause one in four deaths worldwide and are important causes of long-term functional disability arising from tissue damage. The continuing epidemics of tuberculosis, HIV, malaria, and influenza, and the emergence of novel zoonotic pathogens represent major clinical management challenges worldwide. Newer approaches to improving treatment outcomes are needed to reduce the high morbidity and mortality caused by infectious diseases. Recent insights into pathogen-host interactions, pathogenesis, inflammatory pathways, and the host's innate and acquired immune responses are leading to identification and development of a wide range of host-directed therapies with different mechanisms of action. Host-directed therapeutic strategies are now becoming viable adjuncts to standard antimicrobial treatment. Host-directed therapies include commonly used drugs for non-communicable diseases with good safety profiles, immunomodulatory agents, biologics (eg monoclonal antibodies), nutritional products, and cellular therapy using the patient's own immune or bone marrow mesenchymal stromal cells. We discuss clinically relevant examples of progress in identifying host-directed therapies as adjunct treatment options for bacterial, viral, and parasitic infectious diseases.
DOI: 10.1016/S1473-3099(16)00078-5
PubMed: 27036359
Affiliations:
- Afrique du Sud, Allemagne, Arabie saoudite, Espagne, Ghana, Italie, Kenya, Royaume-Uni, Suède, Zambie
- Angleterre, Bavière, Berlin, Catalogne, District de Haute-Bavière, Grand Londres, Latium, Région du Grand Accra, Svealand
- Accra, Barcelone, Berlin, Legon (Ghana), Londres, Munich, Rome, Stockholm
- University College de Londres, Université Louis-et-Maximilien de Munich, Université du Ghana
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Le document en format XML
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DZIF German Centre for Infection Research, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich, Munich, Germany; DZIF German Centre for Infection Research, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Maeurer, Markus" sort="Maeurer, Markus" uniqKey="Maeurer M" first="Markus" last="Maeurer">Markus Maeurer</name><affiliation wicri:level="3"><nlm:affiliation>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Stockholm, Sweden. 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Wallis</name><affiliation wicri:level="1"><nlm:affiliation>Aurum Institute, Johannesburg, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Aurum Institute, Johannesburg</wicri:regionArea><wicri:noRegion>Johannesburg</wicri:noRegion></affiliation></author><author><name sortKey="Kaufmann, Stefan H E" sort="Kaufmann, Stefan H E" uniqKey="Kaufmann S" first="Stefan H E" last="Kaufmann">Stefan H E. Kaufmann</name><affiliation wicri:level="3"><nlm:affiliation>Max Planck Institute for Infection Biology, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max Planck Institute for Infection Biology, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Rustomjee, Roxana" sort="Rustomjee, Roxana" uniqKey="Rustomjee R" first="Roxana" last="Rustomjee">Roxana Rustomjee</name><affiliation wicri:level="1"><nlm:affiliation>South African Medical Research Council, Cape Town, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>South African Medical Research Council, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Mwaba, Peter" sort="Mwaba, Peter" uniqKey="Mwaba P" first="Peter" last="Mwaba">Peter Mwaba</name><affiliation wicri:level="1"><nlm:affiliation>University of Zambia-UCL Medical School (UNZA-UCLMS) Research and Training Project, University Teaching Hospital, Lusaka, Zambia; Ministry of Health, Lusaka, Zambia.</nlm:affiliation><country xml:lang="fr">Zambie</country><wicri:regionArea>University of Zambia-UCL Medical School (UNZA-UCLMS) Research and Training Project, University Teaching Hospital, Lusaka, Zambia; Ministry of Health, Lusaka</wicri:regionArea><wicri:noRegion>Lusaka</wicri:noRegion></affiliation></author><author><name sortKey="Vilaplana, Cris" sort="Vilaplana, Cris" uniqKey="Vilaplana C" first="Cris" last="Vilaplana">Cris Vilaplana</name><affiliation wicri:level="3"><nlm:affiliation>Unitat de Tuberculosi Experimental Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol CIBER Enfermedades Respiratorias, Can Ruti Campus, Edifici Laboratoris de Recerca, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unitat de Tuberculosi Experimental Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol CIBER Enfermedades Respiratorias, Can Ruti Campus, Edifici Laboratoris de Recerca, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Yeboah Manu, Dorothy" sort="Yeboah Manu, Dorothy" uniqKey="Yeboah Manu D" first="Dorothy" last="Yeboah-Manu">Dorothy Yeboah-Manu</name><affiliation wicri:level="4"><nlm:affiliation>Bacteriology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Bacteriology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon</wicri:regionArea><orgName type="university">Université du Ghana</orgName><placeName><settlement type="city">Accra</settlement><settlement type="town">Legon (Ghana)</settlement><region type="region">Région du Grand Accra</region></placeName></affiliation></author><author><name sortKey="Chakaya, Jeremiah" sort="Chakaya, Jeremiah" uniqKey="Chakaya J" first="Jeremiah" last="Chakaya">Jeremiah Chakaya</name><affiliation wicri:level="1"><nlm:affiliation>Kenya Medical Research Institute, Nairobi, Kenya.</nlm:affiliation><country xml:lang="fr">Kenya</country><wicri:regionArea>Kenya Medical Research Institute, Nairobi</wicri:regionArea><wicri:noRegion>Nairobi</wicri:noRegion></affiliation></author><author><name sortKey="Ippolito, Giuseppe" sort="Ippolito, Giuseppe" uniqKey="Ippolito G" first="Giuseppe" last="Ippolito">Giuseppe Ippolito</name><affiliation wicri:level="3"><nlm:affiliation>National Institute for Infectious Diseases, Lazzaro Spallanzani, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>National Institute for Infectious Diseases, Lazzaro Spallanzani, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Azhar, Esam" sort="Azhar, Esam" uniqKey="Azhar E" first="Esam" last="Azhar">Esam Azhar</name><affiliation wicri:level="1"><nlm:affiliation>Special Infectious Agents Unit, King Fahd Medical Research Centre, and Medical Laboratory Technology Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Special Infectious Agents Unit, King Fahd Medical Research Centre, and Medical Laboratory Technology Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Hoelscher, Michael" sort="Hoelscher, Michael" uniqKey="Hoelscher M" first="Michael" last="Hoelscher">Michael Hoelscher</name><affiliation wicri:level="4"><nlm:affiliation>Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich, Munich, Germany; DZIF German Centre for Infection Research, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich, Munich, Germany; DZIF German Centre for Infection Research, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Maeurer, Markus" sort="Maeurer, Markus" uniqKey="Maeurer M" first="Markus" last="Maeurer">Markus Maeurer</name><affiliation wicri:level="3"><nlm:affiliation>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Stockholm, Sweden. Electronic address: markus.maeurer@ki.se.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Infectious diseases</title><idno type="eISSN">1474-4457</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Monoclonal (therapeutic use)</term><term>Cell- and Tissue-Based Therapy (methods)</term><term>Communicable Diseases (immunology)</term><term>Communicable Diseases (therapy)</term><term>Cytokines (therapeutic use)</term><term>Drug Resistance</term><term>Host-Pathogen Interactions (immunology)</term><term>Humans</term><term>Vitamins (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps monoclonaux (usage thérapeutique)</term><term>Cytokines (usage thérapeutique)</term><term>Humains</term><term>Interactions hôte-pathogène (immunologie)</term><term>Maladies transmissibles ()</term><term>Maladies transmissibles (immunologie)</term><term>Résistance aux substances</term><term>Thérapie cellulaire et tissulaire ()</term><term>Vitamines (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Cytokines</term><term>Vitamins</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Interactions hôte-pathogène</term><term>Maladies transmissibles</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Communicable Diseases</term><term>Host-Pathogen Interactions</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Cell- and Tissue-Based Therapy</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Communicable Diseases</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux</term><term>Cytokines</term><term>Vitamines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Resistance</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Maladies transmissibles</term><term>Résistance aux substances</term><term>Thérapie cellulaire et tissulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite extensive global efforts in the fight against killer infectious diseases, they still cause one in four deaths worldwide and are important causes of long-term functional disability arising from tissue damage. The continuing epidemics of tuberculosis, HIV, malaria, and influenza, and the emergence of novel zoonotic pathogens represent major clinical management challenges worldwide. Newer approaches to improving treatment outcomes are needed to reduce the high morbidity and mortality caused by infectious diseases. Recent insights into pathogen-host interactions, pathogenesis, inflammatory pathways, and the host's innate and acquired immune responses are leading to identification and development of a wide range of host-directed therapies with different mechanisms of action. Host-directed therapeutic strategies are now becoming viable adjuncts to standard antimicrobial treatment. Host-directed therapies include commonly used drugs for non-communicable diseases with good safety profiles, immunomodulatory agents, biologics (eg monoclonal antibodies), nutritional products, and cellular therapy using the patient's own immune or bone marrow mesenchymal stromal cells. We discuss clinically relevant examples of progress in identifying host-directed therapies as adjunct treatment options for bacterial, viral, and parasitic infectious diseases.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Allemagne</li><li>Arabie saoudite</li><li>Espagne</li><li>Ghana</li><li>Italie</li><li>Kenya</li><li>Royaume-Uni</li><li>Suède</li><li>Zambie</li></country><region><li>Angleterre</li><li>Bavière</li><li>Berlin</li><li>Catalogne</li><li>District de Haute-Bavière</li><li>Grand Londres</li><li>Latium</li><li>Région du Grand Accra</li><li>Svealand</li></region><settlement><li>Accra</li><li>Barcelone</li><li>Berlin</li><li>Legon (Ghana)</li><li>Londres</li><li>Munich</li><li>Rome</li><li>Stockholm</li></settlement><orgName><li>University College de Londres</li><li>Université Louis-et-Maximilien de Munich</li><li>Université du Ghana</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Zumla, Alimuddin" sort="Zumla, Alimuddin" uniqKey="Zumla A" first="Alimuddin" last="Zumla">Alimuddin Zumla</name></region></country><country name="Suède"><region name="Svealand"><name sortKey="Rao, Martin" sort="Rao, Martin" uniqKey="Rao M" first="Martin" last="Rao">Martin Rao</name></region><name sortKey="Maeurer, Markus" sort="Maeurer, Markus" uniqKey="Maeurer M" first="Markus" last="Maeurer">Markus Maeurer</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Wallis, Robert S" sort="Wallis, Robert S" uniqKey="Wallis R" first="Robert S" last="Wallis">Robert S. Wallis</name></noRegion><name sortKey="Rustomjee, Roxana" sort="Rustomjee, Roxana" uniqKey="Rustomjee R" first="Roxana" last="Rustomjee">Roxana Rustomjee</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Kaufmann, Stefan H E" sort="Kaufmann, Stefan H E" uniqKey="Kaufmann S" first="Stefan H E" last="Kaufmann">Stefan H E. Kaufmann</name></region><name sortKey="Hoelscher, Michael" sort="Hoelscher, Michael" uniqKey="Hoelscher M" first="Michael" last="Hoelscher">Michael Hoelscher</name></country><country name="Zambie"><noRegion><name sortKey="Mwaba, Peter" sort="Mwaba, Peter" uniqKey="Mwaba P" first="Peter" last="Mwaba">Peter Mwaba</name></noRegion></country><country name="Espagne"><region name="Catalogne"><name sortKey="Vilaplana, Cris" sort="Vilaplana, Cris" uniqKey="Vilaplana C" first="Cris" last="Vilaplana">Cris Vilaplana</name></region></country><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Yeboah Manu, Dorothy" sort="Yeboah Manu, Dorothy" uniqKey="Yeboah Manu D" first="Dorothy" last="Yeboah-Manu">Dorothy Yeboah-Manu</name></region></country><country name="Kenya"><noRegion><name sortKey="Chakaya, Jeremiah" sort="Chakaya, Jeremiah" uniqKey="Chakaya J" first="Jeremiah" last="Chakaya">Jeremiah Chakaya</name></noRegion></country><country name="Italie"><region name="Latium"><name sortKey="Ippolito, Giuseppe" sort="Ippolito, Giuseppe" uniqKey="Ippolito G" first="Giuseppe" last="Ippolito">Giuseppe Ippolito</name></region></country><country name="Arabie saoudite"><noRegion><name sortKey="Azhar, Esam" sort="Azhar, Esam" uniqKey="Azhar E" first="Esam" last="Azhar">Esam Azhar</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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